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Melatonin as a therapy in REM sleep behavior disorder patients: an open-labeled pilot study on the possible influence of melatonin on REM-sleep regulation

17 In contrast, dual and triple agonists have primarily been evaluated in adult populations

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However, fluoxetine generally did not show significant improvement in symptoms for either depressed or non-depressed patients, except in one study where it improved depressive symptoms without significantly affecting fatigue levels [190, 191]